Treatment of Natural Killer (NK) Cell activity in unexplained recurrent Spontaneous Abortion

Recurrent spontaneous miscarriage (RSM), defined as ≥2 clinically detectable pregnancy losses before 20 weeks of gestation with the same partner. Many studies have been suggested abnormal natural killer (NK) cell activity can be a high chance division linked with RSM. Aberrant expression of angiogenic cytokines during implantation window in women with RSA is one of the key factors that adversely affect endometrial development, as evidenced by the inadequate expression of various endometrial receptivity markers. This review concerns a brief introduction into the basics of blood vessel development as well as the regulatory mechanisms of this process. This review discussed to work out Intralipid could be consumed as a possibility treatment as a part of RSM. In conclusion Intralipid, bordering on LMWH can overthrow the level of NK cells, which has been accounted for to be estimated angiogenic factors and supportive for increasing RSA results in pregnancy. This review is aimed to produce an evidence-based guidance on treatment of unexplained recurrent spontaneous miscarriage.